Tadalafil Femalefil typically begins working in females within 30 to 60 minutes after ingestion. However, the onset time can vary depending on individual factors like metabolism, overall health, and whether the drug is taken on an empty or full stomach. Though originally developed for erectile dysfunction in men, Femalefil (a female version of tadalafil) is used off-label to improve blood flow, increase sensitivity, and enhance sexual experience in women. Effects may be more noticeable during sexual arousal, and the medication can remain active in the system for up to 36 hours, offering a wide window for potential benefits.